Article
UK multicentre project on assessment of risk of trisomy 21 by maternal age and fetal nuchal-translucency thickness at 10-14 weeks of gestation. Fetal Medicine Foundation First Trimester Screening Group.
Lancet (London, England) - 1 Aug 1998
Snijders R J, Noble P, Sebire N, Souka A, Nicolaides K H
Abstract excerpt
BACKGROUND: Prenatal diagnosis of trisomy 21 currently relies on assessment of risk followed by invasive testing in the 5% of pregnancies at the highest estimated risk. Selection of the high-risk group by a combination of maternal age and second-trimester maternal serum biochemistry gives a detec...
Topics
- Adolescent
- Adult
- Chromosome Aberrations
- Chromosome Disorders
- Crown-Rump Length
- Down Syndrome
- Female
- Fetus
- Follow-Up Studies
- Gestational Age
- Humans
- Karyotyping
- Likelihood Functions
- Maternal Age
- Middle Aged