Article
Use of protein repair therapy in the treatment of cystic fibrosis.
Current opinion in pediatrics - 1 Jun 1998
Rubenstein R C, Zeitlin P L
Abstract excerpt
Disruption in the biosynthesis or function the cystic fibrosis transmembrane conductance regulator (CFTR) results from over 700 different mutations in the CFTR gene. It is useful to classify these mutations by the nature of the resulting defect. Understanding the molecular mechanism that leads to CFTR dysfunction stimulates the design of therapeutic strategies based on restoration of CFTR function to the mutant...
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