Article
Early-onset sensorineural hearing loss and late-onset neurologic complaints caused by a mitochondrial mutation at position 7472.
Archives of otolaryngology--head & neck surgery - 1 Aug 1998
Ensink R J, Verhoeven K, Marres H A, Huygen P L, Padberg G W, ter Laak H, van Camp G, Willems P J, Cremers C W
Abstract excerpt
OBJECTIVES: To detect a mitochondrial mutation responsible for maternally transmitted hearing loss with late-onset neurologic features in a 3-generation Dutch family, and to describe the hearing loss, associated symptoms, and vestibular dysfunction. PATIENTS AND METHODS: All maternally related family members (n = 69) were investigated using standard audiometry. In a selected group, vestibulo-ocular examinations...
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