Article
RETRACTED: BRCA1 required for transcription-coupled repair of oxidative DNA damage.
Science (New York, N.Y.) - 14 Aug 1998
Gowen L C, Avrutskaya A V, Latour A M, Koller B H, Leadon S A
This publication is marked as retracted by the source.
Abstract excerpt
The breast and ovarian cancer susceptibility gene BRCA1 encodes a zinc finger protein of unknown function. Association of the BRCA1 protein with the DNA repair protein Rad51 and changes in the phosphorylation and cellular localization of the protein after exposure to DNA-damaging agents are consistent with a role for BRCA1 in DNA repair. Here, it is shown that mouse embryonic stem cells deficient in BRCA1 are...
Read the complete abstract on PubMedTopics
- Alleles
- Animals
- BRCA1 Protein
- Cell Line
- DNA Damage
- DNA Repair
- Hydrogen Peroxide
- Mice
- Oxidation-Reduction