Article
Genotyping of hepatitis B virus by restriction pattern analysis of a pre-S amplicon.
Journal of virological methods - 1 Jun 1998
Lindh M, Gonzalez J E, Norkrans G, Horal P
Abstract excerpt
A method is described for genotyping of hepatitis B virus (HBV), based on the restriction fragment length polymorphism (RFLP) created by Ava2 and Dpn2 action on an amplified segment of the pre-S region. Analysing 51 database sequences by phylogenetic tree construction and RFLP prediction, the method was shown to be capable of detecting all known genotypes (A-F). The method was applied to 99 serum samples from...
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