Article
Kennedy's disease: unusual molecular pathologic and clinical features.
Neurology - 1 Jul 1998
Shaw P J, Thagesen H, Tomkins J, Slade J Y, Usher P, Jackson A, Curtis A, Bushby K, Ince P G
Abstract excerpt
Two patients with the Kennedy's disease (KD) mutation have been identified in the Newcastle Brain Tissue Bank. One of these patients had presenile dementia as a prominent clinical feature, previously undescribed in KD. The pathologic substrate underlying the cognitive changes in this patient included neuronal depletion and gliosis in the hippocampus and subcortical gliosis in the prefrontal region. Immunostaining...
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