Kennedy's disease: unusual molecular pathologic and clinical features.

doi:10.1212/wnl.51.1.252

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Article

Kennedy's disease: unusual molecular pathologic and clinical features.

Neurology - 1 Jul 1998

Shaw P J, Thagesen H, Tomkins J, Slade J Y, Usher P, Jackson A, Curtis A, Bushby K, Ince P G

Abstract excerpt

Two patients with the Kennedy's disease (KD) mutation have been identified in the Newcastle Brain Tissue Bank. One of these patients had presenile dementia as a prominent clinical feature, previously undescribed in KD. The pathologic substrate underlying the cognitive changes in this patient incl...

Topics

Astrocytes
DNA Mutational Analysis
Gliosis
Humans
Male
Middle Aged
Motor Cortex
Motor Neurons
Muscular Atrophy, Spinal
Mutation
Nerve Degeneration

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