Article
Relative frequencies of cystic fibrosis mutations in The Netherlands as an illustration of significant regional variation in a small country.
Human genetics - 1 May 1998
Collée J M, de Vries H G, Scheffer H, Halley D J, ten Kate L P
Abstract excerpt
Cystic fibrosis (CF) is one of the most common autosomal recessive disorders in white populations. Significant regional differences in CF mutations among affected individuals have been reported. We have studied the geographic distribution of the relative frequencies of the three most common Dutch CF mutations, deltaF508, A455E, and G542X, by analyzing data on area of residence of CF patients. Significantly higher...
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