Article
The clinical course of Canavan disease.
Pediatric neurology - 1 Mar 1998
Traeger E C, Rapin I
Abstract excerpt
Canavan, an autosomal-recessive neurodegenerative disease, is caused by a deficiency of aspartoacylase. Most children are reported to have the infantile form, becoming symptomatic between 3 and 6 months of age, after an unremarkable prenatal and perinatal course. Congenital and juvenile onset forms, although uncommon, do occur. We collected clinical information from the parents of 60 children diagnosed with...
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