[Effect of maternal paternal transmissions on clinical manifestations of CTG repeat on myotonic dystrophy].

Article

[Effect of maternal paternal transmissions on clinical manifestations of CTG repeat on myotonic dystrophy].

Nihon rinsho. Japanese journal of clinical medicine - 1 Dec 1997

Eguchi I, Tsuji S

Abstract excerpt

The increasing size of the CTG repeat in successive generations is considered to the molecular basis for anticipation in DM. Maternal offspring show severe clinical manifestation than paternal transmitted offspring. The intergenerational amplification of this repeat is influenced by the sex of th...

Topics

Alleles
Female
Genomic Imprinting
Humans
Male
Mutation
Myotonic Dystrophy
Pregnancy
RNA Splicing
RNA, Messenger
Severity of Illness Index
Trinucleotide Repeats

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