Article
rim2 (recombination-induced mutation 2) is a new allele of pearl and a mouse model of human Hermansky-Pudlak syndrome (HPS): genetic and physical mapping.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jan 1998
Sagai T, Koide T, Endo M, Tanoue K, Kikkawa Y, Yonekawa H, Ishiguro S, Tamai M, Matsuda Y, Wakana S, Shiroishi T
Abstract excerpt
A mouse mutation, rim2, is one of a series of spontaneous mutations that arose from the intra-MHC recombinants between Japanese wild mouse-derived wm7 and laboratory MHC haplotypes. This mutation is single recessive and characterized by diluted coat color and hypo-pigmentation of the eyes. We map...
Topics
- Albinism, Oculocutaneous
- Alleles
- Animals
- Blood Platelets
- Chromosome Mapping
- Chromosomes, Artificial, Yeast
- Disease Models, Animal
- Female
- Homozygote
- Humans
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Mutant Strains