Linkage disequilibrium and the infinitesimal limit.

Abstract excerpt

Under the classical Fisher-Bulmer infinitesimal model of quantitative genetics, the within-family distribution for an additive trait with no environmental component is Gaussian with mean at the mid-parent value and a variance which is the same for all families. When an additive trait is determined by unlinked loci, the Fisher-Bulmer model can arise in the limit as the number of loci contributing to variation in...

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