Article
Failure of immunologic purging in mantle cell lymphoma assessed by polymerase chain reaction detection of minimal residual disease.
Blood - 15 Nov 1997
Andersen N S, Donovan J W, Borus J S, Poor C M, Neuberg D, Aster J C, Nadler L M, Freedman A S, Gribben J G
Abstract excerpt
To assess the clinical significance of minimal residual disease (MRD) detection by polymerase chain reaction (PCR) we analyzed samples from 26 patients with mantle cell lymphoma (MCL) who had undergone bone marrow transplantation (BMT) at the Dana-Farber Cancer Institute. The BCL-1/IgH translocat...
Topics
- Adult
- Amino Acid Sequence
- Bone Marrow Purging
- Bone Marrow Transplantation
- Female
- Humans
- Immunoglobulin Heavy Chains
- Lymphoma, Non-Hodgkin
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Neoplasm, Residual
- Polymerase Chain Reaction
- Transplantation, Autologous