Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression of the SMN Gene, the Spinal Muscular Atrophy Determining Gene, in the Mammalian Central Nervous System

1 Oct 1997

Abstract excerpt

The survival motor neuron (SMN) gene is the putative disease gene for human spinal muscular atrophy (SMA), an autosomal recessive disorder characterized by progressive degeneration of lower motor neurons. Two copies of the gene, centromeric and telomeric, are present in the same 5q13 chromosomal region in humans. However, only the telomeric gene is affected in SMA. The SMN gene(s) encode(s) a novel protein of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Muscle Physiology and Disorders
Share to Neurogenetic and Muscular Disorders Research
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9302277
DOI: 10.1093/hmg/6.11.1961

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of the SMN Gene, the Spinal Muscular Atrophy Determining Gene, in the Mammalian Central Nervous SystemPMID 9302277Read ↗

The survival motor neuron protein in spinal muscular atrophySemantic proximity Read ↗

Neuronal-Specific Roles of the Survival Motor Neuron ProteinSemantic proximity Read ↗

Survival motor neuron (SMN) protein in rat is expressed as different molecular forms and is developmentally regulatedSemantic proximity Read ↗

Axonal-SMN (a-SMN), a protein isoform of the survival motor neuron gene, is specifically involved in axonogenesisSemantic proximity Read ↗

Reduced survival motor neuron (Smn) gene dose in mice leads to motor neuron degeneration: an animal model for spinal muscular atrophy type IIISemantic proximity Read ↗

SMN deficiency disrupts brain development in a mouse model of severe spinal muscular atrophySemantic proximity Read ↗

Survival motor neuron protein in motor neurons determines synaptic integrity in spinal muscular atrophy.Semantic proximity Read ↗

Deficiency of the Survival of Motor Neuron Protein Impairs mRNA Localization and Local Translation in the Growth Cone of Motor NeuronsSemantic proximity Read ↗

Identification and characterization of a spinal muscular atrophy-determining gene.Semantic proximity Read ↗

[Spinal muscular atrophy: SMN protein deficiency].Semantic proximity Read ↗

Spinal muscular atrophy: a deficiency in a ubiquitous protein; a motor neuron-specific disease.Semantic proximity Read ↗

Genetic circuitry of Survival motor neuron, the gene underlying spinal muscular atrophy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.