Missense mutation of FUT1 and deletion of FUT2 are responsible for Indian Bombay phenotype of ABO blood group system.

doi:10.1006/bbrc.1997.7232

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Article

Missense mutation of FUT1 and deletion of FUT2 are responsible for Indian Bombay phenotype of ABO blood group system.

Biochemical and biophysical research communications - 8 Sept 1997

Koda Y, Soejima M, Johnson P H, Smart E, Kimura H

Abstract excerpt

The Bombay phenotype fails to express the ABH antigens of ABO blood group system on red blood cells and in secretions because of a lack in activities of the H gene (FUT1)- and Secretor gene (FUT2)-encoded alpha (1,2)fucosyltransferases. In this study, we have examined the FUT1 and the FUT2 from t...

Topics

ABO Blood-Group System
Alleles
Animals
COS Cells
Fucosyltransferases
Humans
Mutation
Phenotype
Sequence Deletion
Galactoside 2-alpha-L-fucosyltransferase

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