[Isolated spastic paraparesis disclosing Krabbe disease in adult age].

Abstract excerpt

A 25-year-old woman developed a slowly progressive spastic paraparesis a few weeks after delivering of her first child. A cerebral MRI showed bilateral areas of hyperintensity in T-2 weighted images in the centrum semi-ovale, internal capsule, midbrain and occipital white matter. A profound deficiency of galactosyl/ceramidase activity was demonstrated in leukocytes (< 5 p. 100 of controls) and in cultured...

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