Article
Mutations in the cardiac troponin I gene associated with hypertrophic cardiomyopathy.
Nature genetics - 1 Aug 1997
Kimura A, Harada H, Park J E, Nishi H, Satoh M, Takahashi M, Hiroi S, Sasaoka T, Ohbuchi N, Nakamura T, Koyanagi T, Hwang T H, Choo J A, Chung K S, Hasegawa A, Nagai R, Okazaki O, Nakamura H, Matsuzaki M, Sakamoto T, Toshima H, Koga Y, Imaizumi T, Sasazuki T
Abstract excerpt
Hypertrophic cardiomyopathy (HCM), the most common cause of sudden death in the young, is an autosomal dominant disease characterized by ventricular hypertrophy accompanied by myofibrillar disarrays. Linkage studies and candidate-gene approaches have demonstrated that about half of the patients h...
Topics
- Actins
- Amino Acid Sequence
- Animals
- Arginine
- Base Sequence
- Cardiomyopathy, Hypertrophic
- Carrier Proteins
- DNA, Complementary
- Exons
- Female
- Genetic Linkage
- Glycine
- Humans
- Male