Article
Localization and suppression of a kinetic defect in cystic fibrosis transmembrane conductance regulator folding.
The Journal of biological chemistry - 20 Jun 1997
Qu B H, Strickland E H, Thomas P J
Abstract excerpt
A growing body of evidence indicates that the most common cystic fibrosis-causing mutation, DeltaF508, alters the ability of the cystic fibrosis transmembrane conductance regulator (CFTR) protein to fold and transit to the plasma membrane. Here we present evidence that the DeltaF508 mutation affe...
Topics
- Adenosine Triphosphate
- Binding Sites
- Cloning, Molecular
- Cystic Fibrosis Transmembrane Conductance Regulator
- DNA, Complementary
- Glycerol
- Kinetics
- Mutation
- Protein Conformation
- Protein Folding
- Temperature
- Thermodynamics