Prenatal diagnosis in merosin-deficient congenital muscular dystrophy.

doi:10.1016/s0960-8966(97)00448-3

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Article

Prenatal diagnosis in merosin-deficient congenital muscular dystrophy.

Neuromuscular disorders : NMD - 1 May 1997

Naom I, Sewry C, D'Alessandro M, Topaloglu H, Ferlini A, Wilson L, Dubowitz V, Muntoni F

Abstract excerpt

Prenatal diagnosis was carried out in five merosin-deficient congenital muscular dystrophy (CMD) families. We studied both laminin-alpha 2 chain expression in trophoblast using immunocytochemistry and linkage analysis to the LAMA2 locus. In four families there was good agreement between the immun...

Topics

Antibodies, Monoclonal
Biopsy
Chorionic Villi Sampling
DNA, Satellite
Female
Genetic Markers
Genotype
Humans
Immunohistochemistry
Laminin
Muscular Dystrophies
Pregnancy
Trophoblasts

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