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Article

Machado-Joseph disease gene product identified in lymphocytes and brain.

Biochemical and biophysical research communications - 17 Apr 1997

Wang G, Ide K, Nukina N, Goto J, Ichikawa Y, Uchida K, Sakamoto T, Kanazawa I

Abstract excerpt

Machado-Joseph disease (MJD) is associated with the expansion of an unstable CAG repeat. The existence of an abnormal gene product in MJD was previously suggested with the expanded polyglutamine stretch-specific antibody. However, the product of the normal allele has not previously been identified. We generated monoclonal antibodies against the fusion protein (codon 225-310) of the MJD gene product and then...

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Identifiers

PMID: 9144561
DOI: 10.1006/bbrc.1997.6484

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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Machado-Joseph disease gene product identified in lymphocytes and brain.PMID 9144561Read ↗

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Analysis of CAG trinucleotide expansion associated with Machado-Joseph disease.Semantic proximity Read ↗

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The genomic structure and expression of MJD, the Machado-Joseph disease geneSemantic proximity Read ↗

Evidence for inter-generational instability in the CAG repeat in the MJD1 gene and for conserved haplotypes at flanking markers amongst Japanese and Caucasian subjects with Machado-Joseph disease.Semantic proximity Read ↗

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