Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cloning of the cDNA and Chromosome Localization of the Gene for Human Thymidine Kinase 2

1 Mar 1997

Abstract excerpt

Human thymidine kinase 2 (TK2) is a deoxyribonucleoside kinase that phosphorylates thymidine, deoxycytidine, and deoxyuridine. The enzyme also phosphorylates anti-viral and anti-cancer nucleoside analogs. We have identified an expressed sequence tag cDNA that encoded a 27.5-kDa protein approximately 30% similar to the human deoxycytidine kinase and deoxyguanosine kinase. The protein was expressed in Escherichia...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biochemical and Molecular Research
Share to Cancer-related Molecular Pathways
Share to Chronic Lymphocytic Leukemia Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9079672
DOI: 10.1074/jbc.272.13.8454

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cloning of the cDNA and Chromosome Localization of the Gene for Human Thymidine Kinase 2PMID 9079672Read ↗

Cloning and expression of human deoxyguanosine kinase cDNA.Semantic proximity Read ↗

Human dTMP Kinase: Gene Expression and Enzymatic Activity Coinciding with Cell Cycle Progression and Cell GrowthSemantic proximity Read ↗

Identification of three novel cDNAs for human phosphatidylethanolamine N-methyltransferase and localization of the human gene on chromosome 17p11.2.Semantic proximity Read ↗

Altered gene transcription profiles in fibroblasts harboring either TK2 or DGUOK mutations indicate compensatory mechanisms.Semantic proximity Read ↗

Cloning, expression and characterization of human tissue-specific DNA polymerase lambda2.Semantic proximity Read ↗

Four Deoxynucleoside Kinase Activities from Drosophila melanogaster Are Contained within a Single Monomeric Enzyme, a New Multifunctional Deoxynucleoside KinaseSemantic proximity Read ↗

Molecular insight into mitochondrial DNA depletion syndrome in two patients with novel mutations in the deoxyguanosine kinase and thymidine kinase 2 genes.Semantic proximity Read ↗

Thymidine kinase 2 enzyme kinetics elucidate the mechanism of thymidine-induced mitochondrial DNA depletion.Semantic proximity Read ↗

Human UMP-CMP Kinase 2, a Novel Nucleoside Monophosphate Kinase Localized in MitochondriaSemantic proximity Read ↗

Synergistic effect of deoxynucleosides and AAV gene therapy for thymidine kinase 2 deficiencySemantic proximity Read ↗

Elevated Levels of Thymidylate Synthase Linked to Neoplastic Transformation of Mammalian CellsSemantic proximity Read ↗

Thymidine kinase, thymidylate synthase, and dihydropyrimidine dehydrogenase profiles of cell lines of the National Cancer Institute's Anticancer Drug Screen.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.