Segregation analysis of cryptogenic epilepsy and an empirical test of the validity of the results.

Article

Segregation analysis of cryptogenic epilepsy and an empirical test of the validity of the results.

American journal of human genetics - 1 Mar 1997

Ottman R, Hauser W A, Barker-Cummings C, Lee J H, Risch N

Abstract excerpt

We used POINTER to perform segregation analysis of cryptogenic epilepsy in 1,557 three-generation families (probands and their parents, siblings, and offspring) ascertained from voluntary organizations. Analysis of the full data set indicated that the data were most consistent with an autosomal dominant (AD) model with 61% penetrance of the susceptibility gene. However, subsequent analyses revealed that the...

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