Article
The TSG101 tumor susceptibility gene is located in chromosome 11 band p15 and is mutated in human breast cancer.
Cell - 10 Jan 1997
Li L, Li X, Francke U, Cohen S N
Abstract excerpt
Recent work has identified a mouse gene (tsg101) whose inactivation in fibroblasts results in cellular transformation and the ability to produce metastatic tumors in nude mice. Here, we report that the human homolog, TSG101, which we isolated and mapped to chromosome 11, bands 15.1-15.2, a region proposed to contain tumor suppressor gene(s), is mutated at high frequency in human breast cancer. In 7 of 15...
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- Amino Acid Sequence
- Animals
- Breast
- Breast Neoplasms
- Carcinoma
- Chromosome Mapping
- Chromosomes, Human, Pair 11
- Cloning, Molecular
- Cricetinae
- Cricetulus