Article
Sequence variation at the phenylalanine hydroxylase gene in the British Isles.
American journal of human genetics - 1 Feb 1997
Tyfield L A, Stephenson A, Cockburn F, Harvie A, Bidwell J L, Wood N A, Pilz D T, Harper P, Smith I
Abstract excerpt
Using mutation and haplotype analysis, we have examined the phenylalanine hydroxylase gene in the phenylketonuria populations of four geographical areas of the British Isles: the west of Scotland, southern Wales, and southwestern and southeastern England. The enormous genetic diversity of this lo...
Topics
- Alleles
- Cluster Analysis
- DNA Mutational Analysis
- England
- Exons
- Genetic Variation
- Haplotypes
- Humans
- Minisatellite Repeats
- Mutation
- Nucleic Acid Heteroduplexes
- Phenylalanine Hydroxylase
- Phenylketonurias
- Polymorphism, Single-Stranded Conformational
- Scotland
- Wales