Article
Sequence variation at the phenylalanine hydroxylase gene in the British Isles.
American journal of human genetics - 1 Feb 1997
Tyfield L A, Stephenson A, Cockburn F, Harvie A, Bidwell J L, Wood N A, Pilz D T, Harper P, Smith I
Abstract excerpt
Using mutation and haplotype analysis, we have examined the phenylalanine hydroxylase gene in the phenylketonuria populations of four geographical areas of the British Isles: the west of Scotland, southern Wales, and southwestern and southeastern England. The enormous genetic diversity of this locus within the British Isles is demonstrated in the large number of different mutations characterized and in the...
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