Article
Quantification by flow cytometry of chromosome-17 deletions in Smith-Magenis syndrome patients.
Human genetics - 1 Dec 1996
Trask B J, Mefford H, van den Engh G, Massa H F, Juyal R C, Potocki L, Finucane B, Abuelo D N, Witt D R, Magenis E, Baldini A, Greenberg F, Lupski J R, Patel P I
Abstract excerpt
We have used bivariate flow karyotyping to quantify the deletions involving chromosome 17 in sixteen patients with Smith-Magenis syndrome (SMS). The fluorescence intensities of mitotic chromosomes stained with Hoechst 33258 and chromomycin were quantified in a dual-beam flow cytometer. For each patient, the position of the peak representing the deleted chromosome 17 was compared to those of the normal homologs of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.