Article
Cystic fibrosis mutation detection by hybridization to light-generated DNA probe arrays.
Human mutation - 1 Jan 1996
Cronin M T, Fucini R V, Kim S M, Masino R S, Wespi R M, Miyada C G
Abstract excerpt
We have combined photochemistry and photolithography with solid-phase DNA synthesis chemistry to form a new technology that makes high density oligonucleotide probe array synthesis possible. Hybridization to these two-dimensional arrays containing hundreds or thousands of oligonucleotide probes provides a powerful DNA sequence analysis tool. Two types of light-generated DNA probe arrays have been used to test for...
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