Article
[Nature of mutations disrupting the formation of 6-phosphogluconate dehydrogenase in Drosophila melanogaster, and their suppression].
Molekuliarnaia biologiia - 1 Jan 2000
Gvozdev V A, Gerasimova T I, Kogan G L, Rozovskiĭ Ia M
Abstract excerpt
Molecular nature of lethal and semilethal mutations in the Pgd locus of D. melanogaster coding for 6-phosphogluconate dehydrogenase (6tpgd) was studied. All these mutations affect the structural gene of the Pgd locus: 3 semilethal mutations resulted in altered 6PGD molecules with the decreased catalytic activity; the remaining 8 lethals were "zero" alleles possessing mutant polypeptides inactive but capable to...
Topics
- Alleles
- Animals
- Catalysis
- Drosophila melanogaster
- Epitopes
- Ethyl Methanesulfonate
- Female
- Genes
- Genes, Lethal
- Immunodiffusion
- Isoenzymes
- Male