[Protein and DNA sequencing analyses of transthyretin in familial amyloidotic polyneuropathy].

Abstract excerpt

Recent advances in protein chemistry and the molecular biology of amyloid proteins have led to knowledge of the primary etiology of FAP. The protein product of the gene in question was identified, then the chromosomal location and point mutations in the gene were determined. Diagnosis of the disorder now can be made at the protein and DNA levels. Recombinant techniques for producing variant proteins have been...

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