Nerve growth factor enhances survival and cytotoxic activity of human eosinophils.

Abstract excerpt

Phenotypic change of blood-type eosinophils to tissue-type eosinophils is induced by various cytokines. We examined the effect of nerve growth factor (NGF) as a candidate for a constitutive cytokine which is able to induce the phenotypic change of eosinophils. The viability of human peripheral blood eosinophils cultured for 4 d was increased from a mean of 26% to a mean of 50% (P<0.001) by the addition of NGF (50...

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