Article
Genetic and molecular basis for copper toxicity.
The American journal of clinical nutrition - 1 May 1996
Harris Z L, Gitlin J D
Abstract excerpt
Recent studies resulted in the cloning of the genes responsible for Menkes syndrome and Wilson disease. Despite the distinct clinical phenotypes of these disorders, each gene encodes a highly homologous member of the cation-transport P-type ATPase family. The remarkable evolutionary conservation...
Topics
- Adenosine Triphosphatases
- Amino Acid Sequence
- Animals
- Ceruloplasmin
- Copper
- Disease Models, Animal
- Hepatolenticular Degeneration
- Humans
- Menkes Kinky Hair Syndrome
- Molecular Sequence Data
- Mutation
- Rats