Article
Mucopolysaccharidosis type VI in rats: isolation of cDNAs encoding arylsulfatase B, chromosomal localization of the gene, and identification of the mutation.
Genomics - 10 Oct 1995
Kunieda T, Simonaro C M, Yoshida M, Ikadai H, Levan G, Desnick R J, Schuchman E H
Abstract excerpt
Mucopolysaccharidosis (MPS) type VI, the lysosomal storage disorder caused by the deficiency of arylsulfatase B (ARSB) activity, occurs in humans, cats, and rats. To characterize the molecular lesion(s) causing MPS VI in rats, cDNAs encoding rat ARSB were isolated from a rat liver cDNA library. T...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cats
- Chondro-4-Sulfatase
- Chromosome Mapping
- Cloning, Molecular
- DNA Primers
- DNA, Complementary
- Disease Models, Animal
- Gene Library
- Genotype
- Humans
- Liver
- Molecular Sequence Data