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Article

A human vascular disorder, supravalvular aortic stenosis, maps to chromosome 7.

Proceedings of the National Academy of Sciences of the United States of America - 15 Apr 1993

Ewart A K, Morris C A, Ensing G J, Loker J, Moore C, Leppert M, Keating M

Abstract excerpt

The pathogenesis of vascular disease is unclear, but genetic factors play an important role. In this study we performed linkage analyses in two families with supravalvular aortic stenosis, an inherited vascular disorder that causes narrowing of major arteries and may lead to cardiac overload and failure. DNA markers on the long arm of chromosome 7 (D7S371, D7S395, D7S448, and ELN) were linked to supravalvular...

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Identifiers

PMID: 8475063
DOI: 10.1073/pnas.90.8.3226
PMCID: PMC46272

Genes

ELN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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