Inference of the strength of genotype-disease association from studies comparing offspring with and without parental history of disease.

Abstract excerpt

The association between genetic polymorphisms and a multifactorial disease is generally investigated by case-control studies. However, inference about the genotype-disease association can also be drawn from studies comparing offspring having a parental history of disease with offspring having no parental history. In such studies, differences in genotype frequencies between the two groups of offspring will reflect...

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