Article
Genetic variation around the collagen IV 1a gene locus and proliferative retinopathy in type 2 diabetes mellitus.
Human heredity - 1 Jan 2000
Alcolado J C, Baroni M G, Li S R, Galton D J
Abstract excerpt
The development of proliferative retinopathy in type 2 diabetes mellitus may be under genetic control. A well-documented pathological change in the fundal capillaries of patients with diabetic retinopathy is basement membrane thickening, with an increased amount of collagen IV protein. Variation at the collagen 1a IV gene therefore may explain familial susceptibility to this complication. It has been previously...
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