Genetic variation around the collagen IV 1a gene locus and proliferative retinopathy in type 2 diabetes mellitus.

doi:10.1159/000154129

Back to search

Article

Genetic variation around the collagen IV 1a gene locus and proliferative retinopathy in type 2 diabetes mellitus.

Human heredity - 1 Jan 2000

Alcolado J C, Baroni M G, Li S R, Galton D J

Abstract excerpt

The development of proliferative retinopathy in type 2 diabetes mellitus may be under genetic control. A well-documented pathological change in the fundal capillaries of patients with diabetic retinopathy is basement membrane thickening, with an increased amount of collagen IV protein. Variation...

Topics

Aged
Aged, 80 and over
Alleles
Chromosomes, Human, Pair 13
Collagen
DNA Probes
Diabetes Mellitus, Type 2
Diabetic Retinopathy
Gene Frequency
Genetic Variation
Genotype
Humans
Middle Aged

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.