Article
Exclusion of the neurofibromatosis 1 locus in a family with inherited café-au-lait spots.
American journal of medical genetics - 1 Jun 1993
Brunner H G, Hulsebos T, Steijlen P M, der Kinderen D J, vd Steen A, Hamel B C
Abstract excerpt
We have performed linkage analysis in a small family with autosomal dominant inheritance of multiple café-au-lait spots (CLS) in order to clarify its relationship to classical von Recklinghausen disease (NF 1). We found that an affected woman had transmitted a different haplotype for markers flanking the NF1 gene to both of her affected daughters. These results exclude an allelic mutation of the NF 1 gene on...
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