Article
Isolation of a zinc finger gene consistently deleted in DiGeorge syndrome.
Human molecular genetics - 1 Oct 1993
Aubry M, Demczuk S, Desmaze C, Aikem M, Aurias A, Julien J P, Rouleau G A
Abstract excerpt
DiGeorge syndrome is a human developmental disorder resulting in hypoplasia of the thymus and parathyroids, and conotruncal heart defects. We recently isolated four genes with zinc finger DNA binding motifs mapping to chromosome 22q11.2 DiGeorge critical region. We now report that one of them, ZNF74 gene, is hemizygously deleted in 23 out of 24 DiGeorge syndrome patients tested. ZNF74 mRNA transcripts are...
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