Article
Isolation of bioactive and other oxoaporphine alkaloids from two annonaceous plants, Xylopia aethiopica and Miliusa cf. banacea.
Journal of natural products - 1 Jan 1994
Harrigan G G, Gunatilaka A A, Kingston D G, Chan G W, Johnson R K
Abstract excerpt
The oxoaporphine alkaloids oxophoebine [1] and liriodenine [2] have been isolated from Xylopia aethiopica (Annonaceae). Both showed selective toxicity against DNA repair and recombination deficient mutants of the yeast Saccharomyces cerevisae. Three related but inactive compounds, oxoglaucine [3]...
Topics
- Antineoplastic Agents, Phytogenic
- Aporphines
- Australia
- DNA Repair
- Drug Screening Assays, Antitumor
- Humans
- Indonesia
- KB Cells
- Magnetic Resonance Spectroscopy
- Mutation
- Plant Extracts
- Plants