Article
Identification of an IP3 receptor in endothelial cells.
Journal of cellular physiology - 1 Apr 1994
Bourguignon L Y, Iida N, Sobrin L, Bourguignon G J
Abstract excerpt
In this study we have used saponin to permeabilize bovine endothelial cell membranes in order to directly test the involvement of IP3 in regulating internal Ca2+ release. Our results indicate that the release of internal Ca2+ occurs as early as 1-3 seconds after IP3 addition. This IP3-induced internal Ca2+ release can be inhibited by heparin (an IP3 receptor antagonist). Further binding of [3H]IP3 to...
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