Article
Familial amyloidotic polyneuropathy with late-onset and well-preserved autonomic function: a Japanese kindred with novel mutant transthyretin (Ala97 to Gly).
Journal of the neurological sciences - 1 Jan 1994
Yasuda T, Sobue G, Doyu M, Nakazato M, Shiomi K, Yanagi T, Mitsuma T
Abstract excerpt
We report the characteristics of one patient and two asymptomatic carriers from a Japanese family with familial amyloidotic polyneuropathy (FAP). The clinical features were somatic sensory and motor neuropathy with well-preserved autonomic function and late onset with slow insidious progression....
Topics
- Age of Onset
- Amyloidosis
- Autonomic Nervous System
- Base Sequence
- Biopsy
- Humans
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Myocardium
- Nervous System Diseases
- Pedigree
- Polymerase Chain Reaction
- Prealbumin
- Sural Nerve