Genetic dissection of mechanosensory transduction: mechanoreception-defective mutations of Drosophila.

Abstract excerpt

To identify genes involved in mechanotransduction, Drosophila larvae were screened for X-linked mutations affecting a behavioral response to touch. Many mutations that caused nondevelopmental defects were recovered, among them multiple alleles of the genes uncoordinated (unc) and uncoordinated-like (uncl). Adult flies mutant in these genes showed reduced viability that was associated with behavioral phenotypes...

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