Loss of heterozygosity on chromosome 22 in ovarian carcinoma is distal to and is not accompanied by mutations in NF2 at 22q12.

doi:10.1038/bjc.1994.418

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Article

Loss of heterozygosity on chromosome 22 in ovarian carcinoma is distal to and is not accompanied by mutations in NF2 at 22q12.

British journal of cancer - 1 Nov 1994

Englefield P, Foulkes W D, Campbell I G

Abstract excerpt

Frequent loss of heterozygosity (LOH) has been reported on 22q in ovarian carcinoma, implying the presence of a tumour-suppressor gene. The neurofibromatosis type 2 gene (NF2) at 22q12 is a plausible candidate. Analysis of 9 of the 17 exons of NF2 by single-strand conformational polymorphism (SSC...

Topics

Alleles
Chromosomes, Human, Pair 22
Exons
Female
Gene Deletion
Genes, Neurofibromatosis 2
Heterozygote
Humans
Mutation
Ovarian Neoplasms
Polymorphism, Single-Stranded Conformational

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