Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prevalence of a mutation causing C2 deficiency in systemic lupus erythematosus.

The Journal of rheumatology - 1 Jun 1994

Sullivan K E, Petri M A, Schmeckpeper B J, McLean R H, Winkelstein J A

Abstract excerpt

OBJECTIVE: In an effort to establish whether a 28 base pair (bp) deletion in the gene for the 2nd component of complement (C2) constitutes a significant genetic risk factor for systemic lupus erythematosus (SLE), we determined the frequency of this mutation in SLE and control populations. The MHC associations of this mutation were also established. METHODS: Polymerase chain reaction (PCR) was used to amplify DNA,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Gene Deletion
Share to Gene Frequency

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Homozygote

Share to Molecular Sequence Data

Share to Mutation

Share to Polymerase Chain Reaction

Share to Proteins

Source

Identifiers

PMID: 7932427

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prevalence of a mutation causing C2 deficiency in systemic lupus erythematosus.PMID 7932427Read ↗

C4A deficiency due to a 2 bp insertion is increased in patients with systemic lupus erythematosus.Semantic proximity Read ↗

Strong Association of Combined Genetic Deficiencies in the Classical Complement Pathway With Risk of Systemic Lupus Erythematosus and Primary Sjögren's SyndromeSemantic proximity Read ↗

Polymerase chain reaction based C4AQ0 and C4BQ0 genotyping: association with systemic lupus erythematosus in southwest Han Chinese.Semantic proximity Read ↗

Lupus erythematosus associated with genetically determined deficiency of the second component of the complement.Semantic proximity Read ↗

Lack of evidence of a specific role for C4A gene deficiency in determining disease susceptibility among C4-deficient patients with systemic lupus erythematosus (SLE).Semantic proximity Read ↗

C2 deficiency in blood donors and lupus patients: prevalence, clinical characteristics and HLA-associations in the Brazilian population.Semantic proximity Read ↗

Survey of Turkish systemic lupus erythematosus patients for a particular mutation of C1Q deficiency.Semantic proximity Read ↗

Hereditary Heterozygous C2 Deficiency: Variable Clinical and Serological Manifestations Among Three Sisters.Semantic proximity Read ↗

Frequency in Spanish population of familial complement factor 2 type I deficits and associated HLA haplotypes.Semantic proximity Read ↗

Combined heterozygous deficiency of the classical complement pathway proteins C2 and C4.Semantic proximity Read ↗

Preferential association of a functional variant in complement receptor 2 with antibodies to double-stranded DNA.Semantic proximity Read ↗

Molecular characterization of the complement C1q, C2 and C4 genes in Brazilian patients with juvenile systemic lupus erythematosus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.