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Article

Progressive hyperpigmentation: case report with a clinical, histological, and ultrastructural investigation.

Dermatology (Basel, Switzerland) - 1 Jan 1994

Betts C M, Bardazzi F, Fanti P A, Tosti A, Varotti C

Abstract excerpt

A clinical, histological and ultrastructural study of a 38-year-old woman with generalized progressive hyperpigmentation is reported. Hyperpigmentation started in early infancy, progressed during childhood and has increased to a dark bronze-brown color with 'mottling' in the last 8 years. Histology and electron microscopy revealed epidermal hypermelanosis and 'negroid' distribution of melanosomes in...

Topics

Adult
Epidermis
Female
Genes, Dominant
Humans
Hyperpigmentation
Keratinocytes
Lentigo
Melanins
Melanocytes
Melanosis
Microscopy, Electron

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 7873826
DOI: 10.1159/000246885

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7873826-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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