Article
A model for AIDS pathogenesis.
Statistics in medicine - 1 Jan 2000
Schenzle D
Abstract excerpt
The idea is put forward and analysed numerically, that within an infected person HIV evolves to increase its reproductivity within the population of CD4+ cells. A mathematical model predicts initial viremia and CD4+ cell drop after HIV infection and thereafter a slow progressive decline in the number of CD4+ cells, although for an extended period HIV is kept at a relatively low level by an active immune response....
Topics
- Acquired Immunodeficiency Syndrome
- Antibody Affinity
- Binding Sites, Antibody
- CD4 Antigens
- Disease Progression
- HIV Infections
- Humans
- Immunity, Cellular
- Lymphopenia
- Models, Biological
- Mutation
- Poisson Distribution