Article
Assignment of the zeta-crystallin gene (CRYZ) to human chromosome 1p22-p31 and identification of restriction fragment length polymorphisms.
Genomics - 15 Sept 1994
Heinzmann C, Kojis T L, Gonzalez P, Rao P V, Zigler J S, Polymeropoulos M H, Klisak I, Sparkes R S, Mohandas T, Bateman J B
Abstract excerpt
zeta-Crystallin is a lens protein that has been associated with autosomal dominant congenital cataracts in guinea pigs and thus is a candidate for human congenital cataracts. We have assigned the zeta-crystallin gene (CRYZ) to human chromosome 1 using a Southern panel of 17 human-mouse somatic cell hybrids and regionally localized it to 1p22-p31 by fluorescence in situ hybridization. Five restriction fragment...
Topics
- Alleles
- Animals
- Cataract
- Chromosome Mapping
- Chromosomes, Human, Pair 1
- Crystallins
- Genetic Linkage
- Guinea Pigs
- Humans
- Hybrid Cells
- In Situ Hybridization, Fluorescence