Article
Refining the localization of the PKD2 locus on chromosome 4q by linkage analysis in Spanish families with autosomal dominant polycystic kidney disease type 2.
American journal of human genetics - 1 Jan 1995
San Millán J L, Viribay M, Peral B, Martínez I, Weissenbach J, Moreno F
Abstract excerpt
Autosomal dominant polycystic kidney disease (ADPKD) is a genetically heterogeneous disorder. At least two distinct forms of ADPKD are now well defined. In approximately 86% of affected European families, a gene defect localized to 16p13.3 was responsible for ADPKD, while a second locus has been...
Topics
- Adult
- Aged
- Alleles
- Base Sequence
- Chromosome Mapping
- Chromosomes, Human, Pair 4
- DNA, Satellite
- Female
- Genes, Dominant
- Humans
- Lod Score
- Lymphocytes
- Male
- Middle Aged
- Molecular Sequence Data
- Polycystic Kidney, Autosomal Dominant
- Recombination, Genetic
- Spain