Article
Genetic mapping of the Batten disease locus (CLN3) to the interval D16S288-D16S383 by analysis of haplotypes and allelic association.
Genomics - 15 Jul 1994
Mitchison H M, Taschner P E, O'Rawe A M, de Vos N, Phillips H A, Thompson A D, Kozman H M, Haines J L, Schlumpf K, D'Arigo K
Abstract excerpt
CLN3, the gene for juvenile-onset neuronal ceroid lipofuscinosis (JNCL) or Batten disease, has been localized by genetic linkage analysis to chromosome 16p between loci D16S297 and D16S57. We have now further refined the localization of CLN3 by haplotype analysis using two new microsatellite mark...
Topics
- Alleles
- Base Sequence
- Chromosome Mapping
- Chromosomes, Human, Pair 16
- Crossing Over, Genetic
- DNA, Satellite
- Genetic Markers
- Haplotypes
- Humans
- Linkage Disequilibrium
- Male
- Molecular Sequence Data
- Neuronal Ceroid-Lipofuscinoses
- Recombination, Genetic