Article
Molecular genetic analysis of a family with a history of Hodgkin's disease and dyschondrosteosis.
Leukemia - 1 May 1995
Gokhale D A, Evans D G, Crowther D, Woll P, Watson C J, Dearden S P, Fergusson W D, Stevens R F, Taylor G M
Abstract excerpt
We describe a family in which two sisters with the autosomal dominant skeletal dysplasia, Leri-Weill dyschondrosteosis (LWD), developed Hodgkin's disease (HD) in late adolescence. In a preliminary attempt to identify HD susceptibility gene(s), HLA-typing and linkage analysis were carried out in the family. Using HLA molecular typing, both sisters were found to have inherited a variant of the HD-susceptibility...
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