Article
Molecular genetic analysis of a family with a history of Hodgkin's disease and dyschondrosteosis.
Leukemia - 1 May 1995
Gokhale D A, Evans D G, Crowther D, Woll P, Watson C J, Dearden S P, Fergusson W D, Stevens R F, Taylor G M
Abstract excerpt
We describe a family in which two sisters with the autosomal dominant skeletal dysplasia, Leri-Weill dyschondrosteosis (LWD), developed Hodgkin's disease (HD) in late adolescence. In a preliminary attempt to identify HD susceptibility gene(s), HLA-typing and linkage analysis were carried out in t...
Topics
- Adolescent
- Adult
- Base Sequence
- Chromosomes, Human, Pair 2
- Chromosomes, Human, Pair 8
- Family Health
- Female
- Genetic Linkage
- HLA-DP Antigens
- HLA-DP beta-Chains
- Histocompatibility Antigens Class I
- Histocompatibility Antigens Class II
- Histocompatibility Testing
- Hodgkin Disease
- Humans
- Male
- Middle Aged
- Molecular Sequence Data