Article
Comparison of the ankyrin (AC)n microsatellites in genomic DNA and mRNA reveals absence of one ankyrin mRNA allele in 20% of patients with hereditary spherocytosis.
Blood - 1 Jun 1995
Jarolim P, Rubin H L, Brabec V, Palek J
Abstract excerpt
Combined deficiency of ankyrin and spectrin represents the most common biochemical abnormality in hereditary spherocytosis (HS). To examine whether a decrease in ankyrin mRNA represents a frequent cause of this type of HS, we took advantage of the reported (AC)n microsatellite polymorphism in the...
Topics
- Alleles
- Ankyrins
- Base Sequence
- DNA Mutational Analysis
- DNA, Complementary
- DNA, Satellite
- Gene Expression Regulation
- Genes, Dominant
- Heterozygote
- Humans
- Minisatellite Repeats
- Molecular Sequence Data
- RNA Processing, Post-Transcriptional
- RNA, Messenger
- Spectrin
- Spherocytosis, Hereditary
- Transcription, Genetic