Sporadic ALS and chromosome 22: evidence for a possible neurofilament gene defect.

doi:10.1002/mus.880180510

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Article

Sporadic ALS and chromosome 22: evidence for a possible neurofilament gene defect.

Muscle & nerve - 1 May 1995

Meyer M A, Potter N T

Abstract excerpt

ALS is associated with the P2 blood group phenotype. Molecular evidence now shows the gene encoding this antigen to be on the long arm of human chromosome 22 near the newly discovered gene for heavy neurofilament (NF-H). Since an ALS-type condition can be generated in transgenic mice expressing t...

Topics

Amyotrophic Lateral Sclerosis
Animals
Chromosomes, Human, Pair 22
Humans
Mutation
Neurofilament Proteins

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