Codon 178 mutation of the human prion protein gene in a German family (Backer family): sequencing data from 72-year-old celloidin-embedded brain tissue.

doi:10.1007/BF00294264

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Article

Codon 178 mutation of the human prion protein gene in a German family (Backer family): sequencing data from 72-year-old celloidin-embedded brain tissue.

Acta neuropathologica - 1 Jan 1995

Kretzschmar H A, Neumann M, Stavrou D

Abstract excerpt

Familial Creutzfeldt-Jakob disease was first described in a family from northern Germany in the 1920s (Backer family). PCR amplification of DNA extracted from brain tissue embedded in celloidin 72 years ago shows a GAC to AAC substitution at codon 178 of the prion protein gene. This mutation is a...

Topics

Aged
Base Sequence
Brain
Codon
Creutzfeldt-Jakob Syndrome
DNA Probes
Family
Germany
Humans
Molecular Sequence Data
Mutation
Prions
Sequence Analysis, DNA

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